DSIP, also known as delta sleep-inducing peptide (DSIP), is a sleep-promoting factor which was isolated from rabbit cerebral venous blood in 1977 . In addition to having the ability to promote or induce sleep in animals, DSIP also elicits effects such as thermoregulation, modification in heart rate, blood pressure, and pain . Moreover, DSIP is considered an endogenous neuropeptide which can cross the blood-brain barrier .
How it works
Interestingly, DSIP injection boosts the survival rate of animals under emotional stress and balances various physiological parameters . The way DSIP works is through the activation, or switching on, of the serotonergic system of the brain. Then, DSIP increases the activity of monoamine oxidase A (MAO-A) – using serotonin as a substrate – in the mitochondria (the powerhouse of the cell) . DSIP can cross the blood brain barrier and also can be absorbed by the human gut with being broken down by gut enzymes .