Description
Summary
Growth hormone releasing peptide-6 (GHRP-6) is a synthetic hexapeptide [1], which is known for stimulating food intake and adiposity (the storage of fat) [2]. GHRP-6 is classified as a growth hormone (GH) secretagogue which have previously been described as inducing several processes, including the regulation of food intake and energy balance (homeostasis) [2]. Lastly, GHRP-6 is known as a potent stimulator of growth hormone (GH) secretion [3].
Structure
GHRP-6 is known to target the ghrelin receptor, and is considered an agonist [4].
Source: [5]
How it works
GHRP-6 works through the activation and breakdown of two molecules: phospholipase C and phosphoinositide [6]. This is coupled with an increase in Calcium influx via voltage-dependent calcium channels in cells [6]. GHRP-6 binds the ghrelin receptor. Ghrelin, which is the peptide is mainly produced, or made, in the gastrointestinal tract (GI) and is responsible for regulating various functions such as food intake, behaviour, energy balance (homeostasis) along with glucose balance [3]. GHRP-6 mimics the action of ghrelin, and is a peptide ghrelin agonist [6]
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