Sermorelin is a 29 amino acid analog of the growth hormone-releasing hormone (GHRH) which harbours the ability to stimulate the release of growth hormone (GH) [Cayman Chemical]. Moreover, sermorelin, which is an analog of the GHRH declines during the aging process, has been suggested as a possible alternative to recombinant human growth hormone (rhGH) in aging [Walker, 2006].
Figure 1. Sermorelin consists of 29 amino acids, the first 29 which constitute the 44 amino acid sequence of growth hormone-releasing hormone (GHRH). Sermorelin is able to promote the secretion of growth hormone (GH) from the anterior pituitary [Furman et al., 2017: https://www.sciencedirect.com/science/article/pii/B9780128012383980358].
How it works
Sermorelin has been previously shown to increase serum growth hormone (GH) levels in rats [Cayman Chemical]. Sermorelin has been noted as the shortest synthetic peptide which retains the full biological function/activity of GHRH [Prakash et al., 1999]. In addition to this, sermorelin is made up of the first 29 amino acids of the native GHRH, which has 44 amino acids, meaning that sermorelin contains most amino acids from the naturally occurring growth hormone-releasing hormone (GHRH) [Prakash et al., 1999].
Over time, and in an aging individual, growth hormone (GH) levels decline and this ultimately results in a reduction of lean muscle mass, an increase in body fat, thinning of the skin along with a compromised – reduced – immune system and cardiovascular function [https://www.antiaging-systems.com/articles/327-sermorelin-a-superior-approach-to-growth-hormone-restoration].