Tesamorelin

8.5

Weight Loss

8.0/10

Improved cognition

8.5/10

Energy

9.0/10

Tesamorelin

Hormone Production
Mental Health
Weight Loss

Description

Summary

Tesamorelin, also marketed under the trade name Egrifta, is known as and compared to a synthetic version of human growth hormone-releasing hormone (GHR), which stimulates and initiates the synthesis of endogenous growth hormone [1]. Moreover, tesamorelin is a treatment used for reducing excess abdominal fat in HIV patients who have associated lipodystrophy [1]. Growth hormone (GH) interacts with a variety of cell-specific receptors which go on to influence a range of pharmacodynamic effects in cells [2].

Structure

Figure 1. Structure of tesamorelin. Tesamorelin binds and stimulates the human growth-hormone-releasing (GRF) receptor in a similar manner to endogenous GRF. The pharmaceutical drug Egrifta (which cinatins tesamorelin) is exclusive to reduce excess abdominal fat in HIV-infected patients who suffer from lipo-dystrophy [2]. Tesamorelin has shown stability in human and dog plasma.

How it works

In humans, growth hormone (GH) interacts with certain, specific receptors on cell surfaces. One of the more well-known effects of GH is its role in height growth during childhood via the stimulation of skeletal growth [3]. However, GH has many other important cellular functions including, the regulation and modulation protein, lipid and carbohydrate metabolism [3]. In this regard, deficiencies in GH can lead to more long-term problems and complications across different ages. In children, GH deficiency is characterised by short stature; in adults, GH deficiency is less obvious and can include, excessive body fat, a low bone mineral content, abnormalities in lipids (fats) and also a decrease in insulin sensitivity [3].

Additional information

Weight 0.001 kg

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Tesamorelin

Tesamorelin

Hormone Production
Mental Health
Weight Loss