PT-141

8.8

Energy

9.0/10

Sense Of Well-Being

9.0/10

sexual dysfunction

8.5/10

PT-141

Mental Health
Sexual Performance

Description

PT-141 is a cyclic heptapeptide melanocortin analog which has been documented as being an intranasal treatment for erectile dysfunction [1]. In addition, PT-141 is a seven amino acid analogue of the peptide known as alpha-melanocyte-stimulating hormone (a-MSH) [2]. PT-141 has been heralded as a promising therapeutic agent for the treatment of erectile dysfunction [3].

Structure 

PT-141 (Figure 1), also known as Bremelanotide, was initially synthesized from the Melanotan-2 peptide; in effect, it works by activating melanocortin receptors in the brain, increasing one’s sexual drive.  It has a molar mass of 1,025.2 g/mol and an elimination half-life of 120 minutes in the body.

How it works

PT-141 is a melanocortinergic compound which acts on the melanocortinergic (MC) system [5]. PT-141 function as a synthetic a-melanocyte stimulating hormone [6]. Briefly, the melanocortinergic system is responsible for a range of physiological effects such as, skin pigmentation, salt and food intake regulation, sexual behaviour and penile erection [5]. Moreover, PT-141, as a synthetic heptapeptide, binds to MC receptors 1, 3 and 4 – PT-141 shows high affinity for MC4R compared to MC3R [5]. In addition, PT-141 is considered an active metabolite of melanotan II [7]. The MC3R and MC4R receptors are primarily expressed in the central nervous system (CNS). Specifically, the MCR3 receptor is expressed in the brain, placenta, gut, heart and testis; the MCR4 receptor shows expression in the brain and adipose tissue [8].

Additional information

Weight 0.001 kg

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PT-141

PT-141

Mental Health
Sexual Performance