Angiogenesis

Definition

Angiogenesis is the formation of new blood vessels from pre-existing vasculature. It is a tightly regulated physiological process essential for wound healing, tissue repair, embryonic development, and exercise adaptation. Dysregulated angiogenesis is implicated in conditions ranging from chronic wounds to tumour growth.

How Angiogenesis Works

The process is primarily driven by vascular endothelial growth factor (VEGF) signalling. When tissues become hypoxic or damaged, they release VEGF and other pro-angiogenic factors that bind receptors on endothelial cells, triggering proliferation, migration, and tube formation. The balance between pro-angiogenic factors (VEGF, FGF, angiopoietins) and anti-angiogenic factors (endostatin, thrombospondin) determines whether new vessel formation occurs.

Relevance to Peptide Research

Several research peptides are studied for their angiogenic or anti-angiogenic properties. BPC-157 has been investigated for promoting angiogenesis in wound and tendon healing models, with studies suggesting it upregulates VEGF expression. Thymosin Beta-4 (TB-500) is similarly studied for its role in endothelial cell migration and blood vessel formation. GHK-Cu has shown pro-angiogenic effects in skin remodelling contexts. Understanding angiogenesis mechanisms helps contextualise how these peptides may influence tissue repair pathways.

Related Peptides

Peptide profiles that reference “Angiogenesis” in their research content.