Adipotide

8

Weight Loss

9.0/10

Energy

7.5/10

blood pressure

7.5/10

Adipotide

Hormone Production
Weight Loss

Description

Summary

Adipotide is a peptidomimetic which consists of two units: one called a prohibitin-1-targeting peptide, and a pro-apoptotic helical peptide, making it a chimeric molecule [1 The unit works by disrupting, or interrupting, mitochondrial membranes [1].

Structure

Adipotide targets the prohibitin-1 (PHB1), which then initiates cell death, or apoptosis, of endothelial [2] cells that are associated with white adipose tissue]. White adipose tissue (WAT) is known to store excess energy in the form of triglycerides [3]. Data suggests that large amounts of white fat have been correlated with an increased risk of obesity-related disease/disorders [3].

Figure 1. Source: image adapted from [2]

How it works

Adipotide is a chimeric peptide, meaning it is made up of two components; together this affects the function of prohibitins (PHBs) [2]. The function of adipotide is known to damage the vasculature of adipose tissue, which then interrupts blood supply to the fat storing cells (adipocytes) [2].

Figure 2. Shown here are several drugs which target Prohibitin (PHB). Prohibitin was first described in 1989, and its role has been defined as being a modulator of various signalling pathways which control/regulate cell survival, metabolism and cell inflammation [2]. Source: [2]

Additional information

Weight 0.001 kg

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Adipotide

Adipotide

Hormone Production
Weight Loss